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Article

Caffeine could not efficiently sensitize homologous recombination repair-deficient cells to ionizing radiation-induced killing.

Radiation research - 1 Mar 2003

Wang Huichen, Wang Xiang, Iliakis George, Wang Ya

Abstract excerpt

Caffeine inhibits ATM and ATR, two important checkpoint regulators, abolishes ionizing radiation-induced checkpoint response, and radiosensitizes cells. Radiation-induced DNA double-strand breaks (DSBs) are repaired by two major processes, homologous recombination repair (HRR) and nonhomologous end joining (NHEJ). It remains unclear which repair process, HRR or NHEJ, is affected when the checkpoint responses are...

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Source

Identifiers

PMID: 12600245
DOI: 10.1667/0033-7587(2003)159[0420:ccnesh]2.0.co;2

Genes

ATM
RAD51
ATR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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