Article
Mutations conferring foscarnet resistance in a cohort of patients with acquired immunodeficiency syndrome and cytomegalovirus retinitis.
The Journal of infectious diseases - 1 Mar 2003
Weinberg Adriana, Jabs Douglas A, Chou Sunwen, Martin Barbara K, Lurain Nell S, Forman Michael S, Crumpacker Clyde
Abstract excerpt
The clinical significance of cytomegalovirus (CMV) foscarnet resistance was studied in patients with acquired immunodeficiency syndrome and CMV retinitis. Sequencing of the CMV pol gene was performed in 30 isolates. Phenotypic resistance was characterized by the DNA hybridization assay (DHA) in 30 isolates and by plaque-reduction assay (PRA) in 18 isolates. Nine isolates had foscarnet resistance mutations,...
Topics
- AIDS-Related Opportunistic Infections
- Adult
- Antiviral Agents
- Cohort Studies
- Cytomegalovirus
- Cytomegalovirus Retinitis
- DNA-Directed DNA Polymerase
- Drug Resistance, Viral
- Female
- Foscarnet
- Genotype
- HIV Infections
- Humans