Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutations conferring foscarnet resistance in a cohort of patients with acquired immunodeficiency syndrome and cytomegalovirus retinitis.

The Journal of infectious diseases - 1 Mar 2003

Weinberg Adriana, Jabs Douglas A, Chou Sunwen, Martin Barbara K, Lurain Nell S, Forman Michael S, Crumpacker Clyde

Abstract excerpt

The clinical significance of cytomegalovirus (CMV) foscarnet resistance was studied in patients with acquired immunodeficiency syndrome and CMV retinitis. Sequencing of the CMV pol gene was performed in 30 isolates. Phenotypic resistance was characterized by the DNA hybridization assay (DHA) in 30 isolates and by plaque-reduction assay (PRA) in 18 isolates. Nine isolates had foscarnet resistance mutations,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to AIDS-Related Opportunistic Infections
Share to Antiviral Agents

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cytomegalovirus

Share to DNA-Directed DNA Polymerase

Share to Drug Resistance, Viral

Share to Foscarnet

Share to HIV Infections

Share to Viral Proteins

Source

Identifiers

PMID: 12599051
DOI: 10.1086/368385

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutations conferring foscarnet resistance in a cohort of patients with acquired immunodeficiency syndrome and cytomegalovirus retinitis.PMID 12599051Read ↗

Isolation of foscarnet-resistant human cytomegalovirus patterns of resistance and sensitivity to other antiviral drugs.Semantic proximity Read ↗

Antiviral Drug Resistance of Human CytomegalovirusSemantic proximity Read ↗

Foscarnet resistance mutations mapping to atypical domains of the cytomegalovirus DNA polymerase gene.Semantic proximity Read ↗

Novel mutations in reverse transcriptase of human immunodeficiency virus type 1 reduce susceptibility to foscarnet in laboratory and clinical isolatesSemantic proximity Read ↗

A deletion mutation in region V of the cytomegalovirus DNA polymerase sequence confers multidrug resistance.Semantic proximity Read ↗

Cytomegalovirus (CMV) resistance to antivirals.Semantic proximity Read ↗

Resistance of human cytomegalovirus to antiviral drugs.Semantic proximity Read ↗

Phenotypic and genotypic characterization of acyclovir-resistant herpes simplex viruses from immunocompromised patients.Semantic proximity Read ↗

Genotypic testing improves detection of antiviral resistance in human herpes simplex virus.Semantic proximity Read ↗

Variations in the cytomegalovirus DNA polymerase and phosphotransferase genes in relation to foscarnet and ganciclovir sensitivity.Semantic proximity Read ↗

Genotypic characterization of the DNA polymerase and sensitivity to antiviral compounds of foscarnet-resistant herpes simplex virus type 1 (HSV-1) derived from a foscarnet-sensitive HSV-1 strain.Semantic proximity Read ↗

"The end of innocence" revisited: resistance of herpesviruses to antiviral drugs.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.