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Retinal Guanylyl Cyclase Isozyme 1 Is the Preferential <i>In Vivo</i> Target for Constitutively Active GCAP1 Mutants Causing Congenital Degeneration of Photoreceptors

23 May 2012

Abstract excerpt

Two calcium-sensitive guanylyl cyclase activating proteins (GCAP1 and GCAP2) activate cGMP synthesis in photoreceptor by retinal membrane guanylyl cyclase isozymes (RetGC1 and RetGC2) to expedite recovery, but calcium-insensitive constitutively active GCAP1 mutants cause photoreceptor degeneration in human patients and transgenic mice. Although GCAP1 and GCAP2 can both activate RetGC1 and RetGC2 in vitro, we find...

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PMID: 22623665
DOI: 10.1523/jneurosci.0976-12.2012

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