Article
Endothelium-dependent relaxation in pulmonary arteries of L-NAME-treated Wistar and stroke-prone spontaneously hypertensive rats.
Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi - 1 Oct 2002
Sekiguchi Fumiko, Yamamoto Kazuo, Matsuda Kyoko, Kawata Kyoko, Negishi Maki, Shinomiya Kazuaki, Shimamur Keiichi, Sunano Satoru
Abstract excerpt
To evaluate whether the elevated blood pressure induced by chronic treatment with N(omega)-nitro-L-arginine methyl ester (L-NAME) contributes to an impairment of endothelium-dependent relaxation (EDR), the effects of chronic treatment of Wistar rats with L-NAME on systolic blood pressure, pulmonary arterial blood pressure and EDR of the pulmonary arteries were studied and compared with those of stroke-prone...
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