Decreased flow-induced dilation and increased production of cGMP in spontaneously hypertensive rats.

doi:10.1161/01.hyp.32.6.1098

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Article

Decreased flow-induced dilation and increased production of cGMP in spontaneously hypertensive rats.

Hypertension (Dallas, Tex. : 1979) - 1 Dec 1998

Qiu H Y, Henrion D, Benessiano J, Heymes C, Tournier B, Levy B I

Abstract excerpt

-We investigated flow (shear stress)- and agonist-induced cGMP release in mesenteric vascular beds of spontaneously hypertensive rats (SHR) and normotensive Wistar Kyoto rats (WKY). The mesenteric vascular bed was perfused in situ with Tyrode's solution. Vascular relaxation and cGMP release in th...

Topics

Acetylcholine
Animals
Cyclic GMP
Hypertension
Mesenteric Arteries
Nitric Oxide Synthase
Perfusion
Phenotype
Rats
Rats, Inbred SHR
Rats, Inbred WKY
Vasodilation

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