Article
TERT suppresses apoptotis at a premitochondrial step by a mechanism requiring reverse transcriptase activity and 14-3-3 protein-binding ability.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Apr 2003
Zhang Peisu, Chan Sic L, Fu Weiming, Mendoza Marty, Mattson Mark P
Abstract excerpt
The catalytic subunit of telomerase (TERT) is a reverse transcriptase (RT) that adds a six-base DNA repeat onto chromosome ends and prevents their shortening during successive cell divisions. Telomerase is associated with cell immortality and cancer, which may by related to the ability of TERT to prevent apoptosis by stabilizing telomeres. However, fundamental information concerning the antiapoptotic function of...
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