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Article

Imipenem and expression of multidrug efflux pump in Enterobacter aerogenes.

Biochemical and biophysical research communications - 21 Feb 2003

Bornet Charléric, Chollet Renaud, Malléa Monique, Chevalier Jacqueline, Davin-Regli Anne, Pagès Jean-Marie, Bollet Claude

Abstract excerpt

Imipenem is often used to treat intensive care unit patients infected by Enterobacter aerogenes, but it is leading to an increasing number of antibiotic resistant strains. Clinical isolates and imipenem resistant variants presented a high level of resistance to beta-lactam antibiotic group and to chemically unrelated drugs. We report here that imipenem selects strains which contain active efflux pumps ejecting...

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Identifiers

PMID: 12589810
DOI: 10.1016/s0006-291x(03)00074-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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