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Article

AcrAB efflux pump plays a major role in the antibiotic resistance phenotype of Escherichia coli multiple-antibiotic-resistance (Mar) mutants.

Journal of bacteriology - 1 Jan 1996

Okusu H, Ma D, Nikaido H

Abstract excerpt

Multiple-antibiotic-resistance (Mar) mutants of Escherichia coli are resistant to a wide variety of antibiotics, and increased active efflux is known to be responsible for the resistance to some drugs. The identity of the efflux system, however, has remained unknown. By constructing an isogenic set of E. coli K-12 strains, we showed that the marR1 mutation was incapable of increasing the resistance level in the...

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Identifiers

PMID: 8550435
DOI: 10.1128/jb.178.1.306-308.1996
PMCID: PMC177656

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