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Article

Investigating the importance of proteasome-interaction for Rad23 function.

Current genetics - 1 Jan 2003

Lambertson David, Chen Li, Madura Kiran

Abstract excerpt

Rad23 contributes to diverse cellular functions that include DNA repair, stress response and growth control. An amino-terminal ubiquitin-like (UbL) domain in Rad23 interacts with catalytically active proteasomes and internal sequences bind multi-ubiquitinated proteins. Rad23 regulates the assembly of substrate-linked multi-ubiquitin chains, promotes efficient degradation of model substrates, and plays an...

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Identifiers

PMID: 12589471
DOI: 10.1007/s00294-002-0350-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Investigating the importance of proteasome-interaction for Rad23 function.PMID 12589471Read ↗

Rad23 promotes the targeting of proteolytic substrates to the proteasome.Semantic proximity Read ↗

Ubiquitin-associated (UBA) domains in Rad23 bind ubiquitin and promote inhibition of multi-ubiquitin chain assembly.Semantic proximity Read ↗

Rad23 interaction with the proteasome is regulated by phosphorylation of its ubiquitin-like (UbL) domain.Semantic proximity Read ↗

The moonlighting of RAD23 in DNA repair and protein degradation.Semantic proximity Read ↗

Rad23 stabilizes Rad4 from degradation by the Ub/proteasome pathway.Semantic proximity Read ↗

The deubiquitylating enzyme Ubp12 regulates Rad23-dependent proteasomal degradation.Semantic proximity Read ↗

The Cellular Location of Rad23, a Polyubiquitin Chain-Binding Protein, Plays a Key Role in Its Interaction with Substrates of the Proteasome.Semantic proximity Read ↗

Rad23 ubiquitin-associated domains (UBA) inhibit 26 S proteasome-catalyzed proteolysis by sequestering lysine 48-linked polyubiquitin chains.Semantic proximity Read ↗

The RAD23 family provides an essential connection between the 26S proteasome and ubiquitylated proteins in Arabidopsis.Semantic proximity Read ↗

Ubiquitin-like proteins and Rpn10 play cooperative roles in ubiquitin-dependent proteolysis.Semantic proximity Read ↗

The 19S regulatory complex of the proteasome functions independently of proteolysis in nucleotide excision repair.Semantic proximity Read ↗

Pleiotropic defects caused by loss of the proteasome-interacting factors Rad23 and Rpn10 of Saccharomyces cerevisiae.Semantic proximity Read ↗

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