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Article

The deubiquitylating enzyme Ubp12 regulates Rad23-dependent proteasomal degradation.

Journal of cell science - 1 Oct 2017

Gödderz Daniela, Giovannucci Tatiana A, Laláková Jana, Menéndez-Benito Victoria, Dantuma Nico P

Abstract excerpt

The consecutive actions of the ubiquitin-selective segregase Cdc48 and the ubiquitin shuttle factor Rad23 result in the delivery of ubiquitylated proteins at the proteasome. Here, we show that the deubiquitylating enzyme Ubp12 interacts with Cdc48 and regulates proteasomal degradation of Rad23-dependent substrates in Saccharomyces cerevisiae. Overexpression of Ubp12 results in stabilization of Rad23-dependent...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28966167
DOI: 10.1242/jcs.202622

Genes

UBA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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