Article
Notch4, a non-HLA gene in the MHC is strongly associated with the most severe form of alopecia areata.
Human genetics - 1 Apr 2003
Tazi-Ahnini R, Cork M J, Wengraf D, Wilson A G, Gawkrodger D J, Birch M P, Messenger A G, McDonagh A J G
Abstract excerpt
Alopecia areata (AA) is a disorder primarily affecting the hair and nails in which associated autoimmune or atopic disease is common. Genetically, it is a complex trait with evidence of a role for genes of the major histocompatibility complex (MHC), the interleukin-1 cluster and chromosome 21 in the pathogenesis. The strongest association is with HLA class II alleles, although whether this indicates a direct...
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