Genome-wide meta-analysis in alopecia areata resolves HLA associations and reveals two new susceptibility loci.

doi:10.1038/ncomms6966

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Article

Genome-wide meta-analysis in alopecia areata resolves HLA associations and reveals two new susceptibility loci.

Nature communications - 22 Jan 2015

Betz Regina C, Petukhova Lynn, Ripke Stephan, Huang Hailiang, Menelaou Androniki, Redler Silke, Becker Tim, Heilmann Stefanie, Yamany Tarek, Duvic Madeliene, Hordinsky Maria, Norris David, Price Vera H, Mackay-Wiggan Julian, de Jong Annemieke, DeStefano Gina M, Moebus Susanne, Böhm Markus, Blume-Peytavi Ulrike, Wolff Hans, Lutz Gerhard, Kruse Roland, Bian Li, Amos Christopher I, Lee Annette, Gregersen Peter K, Blaumeiser Bettina, Altshuler David, Clynes Raphael, de Bakker Paul I W, Nöthen Markus M, Daly Mark J, Christiano Angela M

Abstract excerpt

Alopecia areata (AA) is a prevalent autoimmune disease with 10 known susceptibility loci. Here we perform the first meta-analysis of research on AA by combining data from two genome-wide association studies (GWAS), and replication with supplemented ImmunoChip data for a total of 3,253 cases and 7,543 controls. The strongest region of association is the major histocompatibility complex, where we fine-map four...

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PMID: 25608926
DOI: 10.1038/ncomms6966
PMCID: PMC4451186

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