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Alopecia areata susceptibility variant identified by MHC risk haplotype sequencing reproduces symptomatic patched hair loss in mice

2018-04-26

Abstract excerpt

<h4>Background</h4> Alopecia areata (AA) is a highly heritable multifactorial and complex disease. However, no convincing susceptibility gene has yet been pinpointed in the major histocompatibility complex (MHC), a region in the human genome known to be associated with AA as compared to other regions. <h4>Results</h4> By sequencing MHC risk haplotypes, we identified a variant (rs142986308, p.Arg587Trp) in the co...

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Literature Corpus work: 0f7e5525-9024-5f18-82c7-1cb34084cb12
DOI: 10.1101/308197

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