Article
Alopecia areata: updates from the mouse perspective.
The journal of investigative dermatology. Symposium proceedings - 1 Dec 2013
Sundberg John P, Berndt Annerose, Silva Kathleen A, Kennedy Victoria E, Sundberg Beth A, Everts Helen B, Rice Robert H, King Lloyd E
Abstract excerpt
Alopecia areata (AA) is a cell-mediated autoimmune disease that targets actively growing hair follicles in mammals, including humans and mice. Development of the C3H/HeJ spontaneous mouse model AA nearly 20 years ago provided a much needed tool to test the hypotheses and ultimately serve as a preclinical model for drug testing. Discoveries in both human AA patients and the mouse model supported each other and...
Topics
- Alopecia Areata
- Animals
- Disease Models, Animal
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Mice
- Mice, Inbred C3H
- Tretinoin