Article
Alopecia areata susceptibility variant in MHC region impacts expressions of genes contributing to hair keratinization and is involved in hair loss.
EBioMedicine - 1 Jul 2020
Oka Akira, Takagi Atsushi, Komiyama Etsuko, Yoshihara Nagisa, Mano Shuhei, Hosomichi Kazuyoshi, Suzuki Shingo, Haida Yuko, Motosugi Nami, Hatanaka Tomomi, Kimura Minoru, Ueda Mahoko Takahashi, Nakagawa So, Miura Hiromi, Ohtsuka Masato, Tanaka Masayuki, Komiyama Tomoyoshi, Otomo Asako, Hadano Shinji, Mabuchi Tomotaka, Beck Stephan, Inoko Hidetoshi, Ikeda Shigaku
Abstract excerpt
BACKGROUND: Alopecia areata (AA) is considered a highly heritable, T-cell-mediated autoimmune disease of the hair follicle. However, no convincing susceptibility gene has yet been pinpointed in the major histocompatibility complex (MHC), a genome region known to be associated with AA as compared to other regions. METHODS: We engineered mice carrying AA risk allele identified by haplotype sequencing for the MHC...
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