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Article

Transcriptional activation of hTERT, the human telomerase reverse transcriptase, by nuclear factor of activated T cells.

The Journal of biological chemistry - 18 Dec 2009

Chebel Amel, Rouault Jean-Pierre, Urbanowicz Iwona, Baseggio Lucile, Chien Wei-Wen, Salles Gilles, Ffrench Martine

Abstract excerpt

Telomerase is essential for telomere maintenance, and its activation is thought to be a critical step in cellular immortalization and tumorigenesis. Human telomerase reverse transcriptase (hTERT) is a major component of telomerase activity. We show here that hTERT is expressed soon after lymphocyte activation and that its expression is inhibited by rapamycin, wortmannin, and FK506, which was the most potent...

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Identifiers

PMID: 19843528
DOI: 10.1074/jbc.M109.009183
PMCID: PMC2791003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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