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Article

The influence of hepatitis B virus genotype on the development of lamivudine resistance during long-term treatment.

Journal of hepatology - 1 Mar 2003

Akuta Norio, Suzuki Fumitaka, Kobayashi Mariko, Tsubota Akihito, Suzuki Yoshiyuki, Hosaka Tetsuya, Someya Takashi, Kobayashi Masahiro, Saitoh Satoshi, Arase Yasuji, Ikeda Kenji, Kumada Hiromitsu

Abstract excerpt

BACKGROUND/AIMS: Genotype-dependent development of lamivudine resistance in hepatitis B virus (HBV) has not been reported. METHODS: We determined the cumulative rate of emergence of YMDD motif mutant in 213 Japanese patients with chronic hepatitis B infected with genotype A, B, or C and treated with lamivudine for more than 1 year. RESULTS: The emergence rate of lamivudine resistance was independent of the...

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Identifiers

PMID: 12586297
DOI: 10.1016/s0168-8278(02)00410-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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