Article
Severe acute exacerbation of liver disease may reduce or delay emergence of YMDD motif mutants in long-term lamivudine therapy for hepatitis B e antigen-positive chronic hepatitis B.
Journal of medical virology - 1 May 2004
Tsubota Akihito, Arase Yasuji, Suzuki Fumitaka, Kobayashi Mariko, Matsuda Marie, Sato Junko, Suzuki Yoshiyuki, Akuta Norio, Sezaki Hitomi, Hosaka Tetsuya, Someya Takashi, Kobayashi Masahiro, Saitoh Satoshi, Ikeda Kenji, Kumada Hiromitsu
Abstract excerpt
The pretherapy factors that could influence the emergence of resistant hepatitis B virus (HBV) tyrosine-methionine-aspartate-aspartate (YMDD) motif mutants against lamivudine are not fully known in prolonged lamivudine therapy for hepatitis B e antigen (HBeAg)-positive chronic hepatitis B. We ana...
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