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Article

Virological and biochemical relapse according to YMDD motif mutant type during long-term lamivudine monotherapy.

Journal of medical virology - 1 Dec 2003

Akuta Norio, Suzuki Fumitaka, Kobayashi Mariko, Matsuda Marie, Sato Junko, Takagi Kimiko, Tsubota Akihito, Suzuki Yoshiyuki, Hosaka Tetsuya, Someya Takashi, Kobayashi Masahiro, Saitoh Satoshi, Arase Yasuji, Ikeda Kenji, Kumada Hiromitsu

Abstract excerpt

Whether the type of lamivudine-resistant virus in hepatitis B virus (HBV) influences the clinical outcome, it is not completely understood. We evaluated the serial changes in YMDD motif mutant in 60 Japanese genotype C-HBV patients who received long-term lamivudine monotherapy. YIDD or YVDD alone tended to stop shifting to the mixed type (YVDD and YIDD) within 12 months after the detection of mutant virus. Hence,...

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Identifiers

PMID: 14556262
DOI: 10.1002/jmv.10519

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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