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Article

Alpha6beta1 integrin induces proteasome-mediated cleavage of erbB2 in breast cancer cells.

Oncogene - 13 Feb 2003

Shimizu Hajime, Seiki Takashi, Asada Makoto, Yoshimatsu Kentaro, Koyama Noriyuki

Abstract excerpt

ErbB2 and alpha6 integrin have been implicated in malignancy of breast cancer cells. Here we have determined the influence of alpha6beta1 integrin on erbB2 signaling in anchorage-independent growth, using MDA-MB435 breast cancer cells. Firstly, we transfected the cells with erbB2 cDNA, and isolated cells with high or low levels of alpha6beta1 integrin by cell sorting (alpha6H-ErbB and alpha6L-ErbB). We found that...

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Source

Identifiers

PMID: 12584562
DOI: 10.1038/sj.onc.1206203

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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