Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cbl-mediated ubiquitination of alpha5 integrin subunit mediates fibronectin-dependent osteoblast detachment and apoptosis induced by FGFR2 activation.

Journal of cell science - 15 Mar 2005

Kaabeche Karim, Guenou Hind, Bouvard Daniel, Didelot Nadège, Listrat Antoine, Marie Pierre J

Abstract excerpt

Fibroblast growth factor receptor signaling is an important mechanism regulating osteoblast function. To gain an insight into the regulatory role of FGF receptor-2 (FGFR2) signaling in osteoblasts, we investigated integrin-mediated attachment and cell survival in human calvarial osteoblasts expre...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetylcysteine
Share to Acrocephalosyndactylia
Share to Caspase 9

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cysteine Proteinase Inhibitors

Share to Phosphotyrosine

Share to Proteasome Inhibitors

Share to Proto-Oncogene Proteins c-cbl

Share to Receptor, Fibroblast Growth Factor, Type 2

Source

Identifiers

PMID: 15728256
DOI: 10.1242/jcs.01679

Genes

FGFR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15728256-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cbl-mediated ubiquitination of alpha5 integrin subunit mediates fibronectin-dependent osteoblast detachment and apoptosis induced by FGFR2 activation.PMID 15728256Read ↗

FGFR2-Cbl interaction in lipid rafts triggers attenuation of PI3K/Akt signaling and osteoblast survival.Semantic proximity Read ↗

Cbl-mediated degradation of Lyn and Fyn induced by constitutive fibroblast growth factor receptor-2 activation supports osteoblast differentiation.Semantic proximity Read ↗

Promotion of Osteoblast Differentiation in Mesenchymal Cells Through Cbl-Mediated Control of STAT5 ActivitySemantic proximity Read ↗

Proapoptotic fibronectin fragment induces the degradation of ubiquitinated p53 via proteasomes in periodontal ligament cells.Semantic proximity Read ↗

Ligand binding induces Cbl-dependent EphB1 receptor degradation through the lysosomal pathway.Semantic proximity Read ↗

Alpha6beta1 integrin induces proteasome-mediated cleavage of erbB2 in breast cancer cells.Semantic proximity Read ↗

Targeting the E3 ubiquitin casitas B-lineage lymphoma decreases osteosarcoma cell growth and survival and reduces tumorigenesisSemantic proximity Read ↗

The multi-adaptor proto-oncoprotein Cbl is a key regulator of Rac and actin assembly.Semantic proximity Read ↗

Regulation of osteoclast apoptosis by ubiquitylation of proapoptotic BH3‐only Bcl‐2 family member BimSemantic proximity Read ↗

Negative regulation of EGFR-Vav2 signaling axis by Cbl ubiquitin ligase controls EGF receptor-mediated epithelial cell adherens junction dynamics and cell migration.Semantic proximity Read ↗

Direct binding of Cbl to Tyr568 and Tyr936 of the stem cell factor receptor/c-Kit is required for ligand-induced ubiquitination, internalization and degradation.Semantic proximity Read ↗

Distinct roles of fibroblast growth factor receptor 1 and 2 in regulating cell survival and epithelial-mesenchymal transition.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.