Article
Increased levels of alpha6 integrins are associated with the metastatic phenotype of human breast cancer cells.
Clinical & experimental metastasis - 1 Jun 1999
Mukhopadhyay R, Theriault R L, Price J E
Abstract excerpt
Integrins play an important role in interactions between cells and the extracellular matrix, and thus have a potential role in metastasis. Expression levels of alpha6, beta1 and beta4 integrin sub-units were measured in a panel of human breast cancer cell lines by RT/PCR, immunoprecipitation and flow cytometry. All the lines expressed alpha6, with the highest levels in the MDA-MB-231 and MDA-MB-435 cells. These...
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