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Article

Two subunits of glycosylphosphatidylinositol transamidase, GPI8 and PIG-T, form a functionally important intermolecular disulfide bridge.

The Journal of biological chemistry - 18 Apr 2003

Ohishi Kazuhito, Nagamune Kisaburo, Maeda Yusuke, Kinoshita Taroh

Abstract excerpt

Many eukaryotic proteins are tethered to the plasma membrane via glycosylphosphatidylinositol (GPI). GPI transamidase is localized in the endoplasmic reticulum and mediates post-translational transfer of preformed GPI to proteins bearing a carboxyl-terminal GPI attachment signal. Mammalian GPI transamidase is a multimeric complex consisting of at least five subunits. Here we report that two subunits of mammalian...

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Identifiers

PMID: 12582175
DOI: 10.1074/jbc.M300586200

Genes

GPI

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Two subunits of glycosylphosphatidylinositol transamidase, GPI8 and PIG-T, form a functionally important intermolecular disulfide bridge.PMID 12582175Read ↗

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Functional Analysis of the GPI Transamidase Complex by Screening for Amino Acid Mutations in Each Subunit.Semantic proximity Read ↗

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A conserved proline in the last transmembrane segment of Gaa1 is required for glycosylphosphatidylinositol (GPI) recognition by GPI transamidase.Semantic proximity Read ↗

Elimination of GPI2 suppresses glycosylphosphatidylinositol GlcNAc transferase activity and alters GPI glycan modification in <i>Trypanosoma brucei</i>Semantic proximity Read ↗

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Gaa1p and gpi8p are components of a glycosylphosphatidylinositol (GPI) transamidase that mediates attachment of GPI to proteins.Semantic proximity Read ↗

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Molecular insights into biogenesis of glycosylphosphatidylinositol anchor proteinsSemantic proximity Read ↗

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