Article
TbGPI16 is an essential component of GPI transamidase in Trypanosoma brucei.
FEBS letters - 23 Jan 2006
Hong Yeonchul, Nagamune Kisaburo, Ohishi Kazuhito, Morita Yasu S, Ashida Hisashi, Maeda Yusuke, Kinoshita Taroh
Abstract excerpt
Glycosylphosphatidylinositol (GPI) is widely used by eukaryotic cell surface proteins for membrane attachment. De novo synthesized GPI precursors are attached to proteins post-translationally by the enzyme complex, GPI transamidase. TbGPI16, a component of the trypanosome transamidase, shares similarity with human PIG-T. Here, we show that TbGPI16 is the orthologue of PIG-T and an essential component of GPI...
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