Article
Stratifin in ocular surface squamous neoplasia and its association with p53.
Acta ophthalmologica - 1 Dec 2021
Chauhan Sheetal, Sen Seema, Chauhan Shyam S, Pushker Neelam, Tandon Radhika, Kashyap Seema, Vanathi Murugesan, Bajaj Mandeep S
Abstract excerpt
PURPOSE: Sunlight-induced p53 mutations are known to contribute towards increased risk of ocular surface squamous neoplasia (OSSN). Stratifin (14-3-3σ)/HEM (human epithelial marker) is a p53-mediated inhibitor of cell cycle progression and has been shown to be a target of epigenetic deregulation in various carcinomas. In the present study, Stratifin expression, its promoter methylation status as well as...
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