Article
Kinetic analyses reveal potent and early blockade of hepatitis C virus assembly by NS5A inhibitors.
Gastroenterology - 1 Aug 2014
McGivern David R, Masaki Takahiro, Williford Sara, Ingravallo Paul, Feng Zongdi, Lahser Frederick, Asante-Appiah Ernest, Neddermann Petra, De Francesco Raffaele, Howe Anita Y, Lemon Stanley M
Abstract excerpt
BACKGROUND & AIMS: All-oral regimens combining different classes of direct-acting antivirals (DAA) are highly effective for treatment of patients with chronic hepatitis C. NS5A inhibitors will likely form a component of future interferon-sparing treatment regimens. However, despite their potential, the detailed mechanism of action of NS5A inhibitors is unclear. To study their mechanisms, we compared their...
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