Selective Upregulation of Transcripts for Six Molecules Related to T Cell Costimulation and Phagocyte Recruitment and Activation among 734 Immunity-Related Genes in the Brain during Perforin-Dependent, CD8 + T Cell-Mediated Elimination of Toxoplasma gondii Cysts

Abstract excerpt

T. gondii establishes a chronic infection by forming tissue cysts, which can grow into sizes greater than 50 μm in diameter as a consequence of containing hundreds to thousands of organisms surrounded by the cyst wall within infected cells. Our recent studies using murine models uncovered that CD8 + cytotoxic T cells penetrate into the cysts in a perforin-dependent manner and induce their elimination, which is...

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