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High-mobility group A1 proteins are overexpressed in human leukaemias

9 May 2003

Abstract excerpt

High-mobility group A (HMGA) proteins are non-histone nuclear proteins that bind DNA and several transcription factors. They are involved in the regulation of chromatin structure and function. HMGA protein expression is low in normal adult tissues, but abundant during embryonic development and in several human tumours. Rearrangements of the HMGA genes have been frequently detected in human benign tumours of...

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PMID: 12573034
DOI: 10.1042/bj20021493

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