Article
IL18 polymorphism is associated with an increased risk of Crohn's disease.
Journal of gastroenterology - 1 Nov 2002
Tamura Kazuo, Fukuda Yoshihiro, Sashio Hiroko, Takeda Naohisa, Bamba Hiroko, Kosaka Tadashi, Fukui Shin, Sawada Koji, Tamura Kazutami, Satomi Masamichi, Yamada Takahiro, Yamamura Takehira, Yamamoto Yoshihiro, Furuyama Jun-ichi, Okamura Haruki, Shimoyama Takashi
Abstract excerpt
BACKGROUND: The etiology of inflammatory bowel disease, which includes ulcerative colitis and Crohn's disease, has not yet been made clear. However, inflammatory bowel disease is recognized as a multifactorial disease, and innate genetic factors might contribute to the pathogenesis. Cytokine genes are thought to be important in inflammatory bowel disease. Recently, interleukin 18, cloned as a novel...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.