Article
CD44 variant isoforms on blood leukocytes in chronic inflammatory bowel disease and other systemic autoimmune diseases.
Laboratory investigation; a journal of technical methods and pathology - 1 Jun 1999
Wittig B, Seiter S, Schmidt D S, Zuber M, Neurath M, Zöller M
Abstract excerpt
We have described recently that TNBS-induced colitis, an animal model of chronic inflammatory bowel disease (IBD), can be cured by treatment with anti-CD44v7. This finding led us to evaluate whether CD44v7 may be of functional importance in patients with IBD. Expression of CD44 variant isoforms (CD44v) has been evaluated on PBMC of 46 patients with IBD, 43 patients with autoimmune diseases not affecting the...
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