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Article

Mechanisms Controlling Sensitivity to Platinum Complexes: Role of p53 and DNA Mismatch Repair

1 Feb 2003

Abstract excerpt

Although cisplatin is effective in the treatment of different types of tumors, resistance to treatment is a major limitation. In an attempt of overcoming resistance mechanisms, a large effort has been made to generate compounds with a different geometry. At present, the most clinically relevant compounds include mononuclear (i.e. oxaliplatin) as well as multinuclear platinum complexes (i.e. BBR 3464). The...

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PMID: 12570658
DOI: 10.2174/1568009033333727

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