Carboplatin: molecular mechanisms of action associated with chemoresistance

Abstract excerpt

Carboplatin is a derivative of cisplatin; it has a similar mechanism of action, but differs in terms of structure and toxicity. It was approved by the FDA in the 1980s and since then it has been widely used in the treatment of several tumor types. This agent is characterized by its ability to generate lesions in DNA through the formation of adducts with platinum, thereby inhibiting replication and transcription an...

Topics

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• DNA and Nucleic Acid Chemistry
• Ferrocene Chemistry and Applications
• Metal complexes synthesis and properties

Identifiers and source

Literature Corpus work

a4ab9c57-8bcb-581f-8b40-a46e73688b71

DOI

10.1590/s1984-82502014000400004