Article
The dwarf phenotype in GH240B mice, haploinsufficient for the autism candidate gene Neurobeachin, is caused by ectopic expression of recombinant human growth hormone.
PloS one - 1 Jan 2014
Nuytens Kim, Tuand Krizia, Fu Quili, Stijnen Pieter, Pruniau Vincent, Meulemans Sandra, Vankelecom Hugo, Creemers John W M
Abstract excerpt
Two knockout mouse models for the autism candidate gene Neurobeachin (Nbea) have been generated independently. Although both models have similar phenotypes, one striking difference is the dwarf phenotype observed in the heterozygous configuration of the GH240B model that is generated by the serendipitous insertion of a promoterless human growth hormone (hGH) genomic fragment in the Nbea gene. In order to...
Topics
- Animals
- Autistic Disorder
- Carrier Proteins
- Disease Models, Animal
- Dwarfism
- Gene Expression
- Haploinsufficiency
- Human Growth Hormone
- Humans
- Hypothalamus