Article
Tissue-specific modifier alleles determine Mertk loss-of-function traits.
eLife - 15 Aug 2022
Akalu Yemsratch T, Mercau Maria E, Ansems Marleen, Hughes Lindsey D, Nevin James, Alberto Emily J, Liu Xinran N, He Li-Zhen, Alvarado Diego, Keler Tibor, Kong Yong, Philbrick William M, Bosenberg Marcus, Finnemann Silvia C, Iavarone Antonio, Lasorella Anna, Rothlin Carla V, Ghosh Sourav
Abstract excerpt
Knockout (KO) mouse models play critical roles in elucidating biological processes behind disease-associated or disease-resistant traits. As a presumed consequence of gene KO, mice display certain phenotypes. Based on insight into the molecular role of said gene in a biological process, it is inferred that the particular biological process causally underlies the trait. This approach has been crucial towards...
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