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Article

A microbeam study of DNA double-strand breaks in bystander primary human fibroblasts

1 Dec 2006

Abstract excerpt

Radiation-induced bystander effect has been well documented. However, the mechanisms are poorly understood. How we incorporate this effect into the classical models of risk assessment remains an open question. Here, the induction of bystander effect was studied by assessing DNA double-strand break (DSB) formation in situ with the rapid and sensitive gamma-H2AX focus formation assay. Utilising the Columbia...

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PMID: 17164279
DOI: 10.1093/rpd/ncl461

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