Article
Possible parent-of-origin effect of Dopa decarboxylase in susceptibility to bipolar affective disorder.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Feb 2003
Børglum A D, Kirov G, Craddock N, Mors O, Muir W, Murray V, McKee I, Collier D A, Ewald H, Owen M J, Blackwood D, Kruse T A
Abstract excerpt
Dopa decarboxylase (DDC) catalyses the synthesis of both dopamine and serotonin as well as trace amines suggested to possess neuromodulating capabilities. We have previously reported evidence suggesting an association between DDC and bipolar affective disorder (BPAD) [Børglum et al., 1999]. To further investigate the possible role of DDC in BPAD, we analyzed a 1- and a 4-bp deletion variant-both of putative...
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