Article
Support of the histaminergic hypothesis in Tourette syndrome: association of the histamine decarboxylase gene in a large sample of families.
Journal of medical genetics - 1 Nov 2013
Karagiannidis Iordanis, Dehning Sandra, Sandor Paul, Tarnok Zsanett, Rizzo Renata, Wolanczyk Tomasz, Madruga-Garrido Marcos, Hebebrand Johannes, Nöthen Markus M, Lehmkuhl Gerd, Farkas Luca, Nagy Peter, Szymanska Urszula, Anastasiou Zachos, Stathias Vasileios, Androutsos Christos, Tsironi Vaia, Koumoula Anastasia, Barta Csaba, Zill Peter, Mir Pablo, Müller Norbert, Barr Cathy, Paschou Peristera
Abstract excerpt
BACKGROUND: Gilles de la Tourette Syndrome is a neurodevelopmental disorder that is caused by the interaction of environment with a complex genetic background. The genetic etiology of the disorder remains, so far, elusive, although multiple promising leads have been recently reported. The recent implication of the histamine decarboxylase (HDC) gene, the key enzyme in histamine production, raises the intriguing...
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