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Article

Proximity of Chromosomal Loci That Participate in Radiation-Induced Rearrangements in Human Cells

6 Oct 2000

Abstract excerpt

Rearrangements involving the RET gene are common in radiation-associated papillary thyroid cancer (PTC). The RET/PTC1 type of rearrangement is an inversion of chromosome 10 mediated by illegitimate recombination between the RET and the H4 genes, which are 30 megabases apart. Here we ask whether despite the great linear distance between them, RET and H4 recombination might be promoted by their proximity in the...

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PMID: 11021799
DOI: 10.1126/science.290.5489.138

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