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Article

Identification and characterization of functional single nucleotide polymorphisms (SNPs) in Axin 1 gene: a molecular dynamics approach.

Cell biochemistry and biophysics - 1 Jun 2018

Khan Imran, Ansari Irfan A, Singh Pratichi, Dass J Febin Prabhu, Khan Fahad

Abstract excerpt

Wnt signaling pathway has been reported to play crucial role in intestinal crypt formation and deregulation of this pathway is responsible for colorectal cancer initiation and progression. Axin 1, a scaffold protein, play pivotal role in the regulation of Wnt/β-catenin signaling pathway and has been found to be mutated in several cancers; primarily in colon cancer. Considering its crucial role, a structural and...

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PMID: 28770488
DOI: 10.1007/s12013-017-0818-1

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Identification and characterization of functional single nucleotide polymorphisms (SNPs) in Axin 1 gene: a molecular dynamics approach.PMID 28770488Read ↗

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