Article
Relation of streptococcal pyrogenic exotoxin C as a causative superantigen for Kawasaki disease.
Pediatric research - 1 Mar 2003
Yoshioka Takeshi, Matsutani Takaji, Toyosaki-Maeda Tomoko, Suzuki Hiroyuki, Uemura Sigeru, Suzuki Ryuji, Koike Michio, Hinuma Yorio
Abstract excerpt
We previously reported that the frequency of TCRBV2 and TCRBV6S5-bearing T-cells was high in patients in the acute phase of Kawasaki disease (KD) and that streptococcal pyrogenic exotoxin C (SPE-C) was a potent stimulator of these TCRBV-bearing T-cells. To further elucidate the pathogenesis of KD, we examined the T-cell receptor (TCR) repertoire, human leukocyte antigen (HLA)-DRB1 genotype, and antibody responses...
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