Article
Natural allelic variants of breast cancer resistance protein (BCRP) and their relationship to BCRP expression in human intestine.
Pharmacogenetics - 1 Jan 2003
Zamber Charis P, Lamba Jatinder K, Yasuda Kazuto, Farnum Jennifer, Thummel Kenneth, Schuetz John D, Schuetz Erin G
Abstract excerpt
The aim of this study was to identify the extent of genetic variability in breast cancer resistance protein (BCRP) in humans. We first analysed the sequence of BCRP cDNA from human livers and from human intestines phenotyped for expression of intestinal BCRP. We then determined the frequency of all known coding single nucleotide polymorphisms (cSNPs) using DNA from individuals representing 11 different ethnic...
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