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Article

Chromatin loosening by poly(ADP)-ribose polymerase (PARP) at Drosophila puff loci.

Science (New York, N.Y.) - 24 Jan 2003

Tulin Alexei, Spradling Allan

Abstract excerpt

Steroid response and stress-activated genes such as hsp70 undergo puffing in Drosophila larval salivary glands, a local loosening of polytene chromatin structure associated with gene induction. We find that puffs acquire elevated levels of adenosine diphosphate (ADP)-ribose modified proteins and that poly(ADP)-ribose polymerase (PARP) is required to produce normal-sized puffs and normal amounts of Hsp70 after...

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Identifiers

PMID: 12543974
DOI: 10.1126/science.1078764

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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