Article
The C-174G promoter polymorphism of the IL-6 gene affects energy expenditure and insulin sensitivity.
Diabetes - 1 Feb 2003
Kubaszek Agata, Pihlajamäki Jussi, Punnonen Kari, Karhapää Pauli, Vauhkonen Ilkka, Laakso Markku
Abstract excerpt
Interleukin-6 (IL-6) is a pleiotropic cytokine expressed in many tissues. IL-6 null mice show low energy expenditure, but the effect of the variants of the IL-6 gene on energy expenditure has not been previously studied in humans. Therefore, we investigated the effect of the C-174G promoter polymorphism of the IL-6 gene on energy expenditure, measured by indirect calorimetry in healthy Finnish subjects (n = 124)....
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