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Article

DNA alkylation damage as a sensor of nitrosative stress in Mycobacterium tuberculosis.

Infection and immunity - 1 Feb 2003

Durbach Steven I, Springer Burkhard, Machowski Edith E, North Robert J, Papavinasasundaram K G, Colston M Jo, Böttger Erik C, Mizrahi Valerie

Abstract excerpt

One of the cellular consequences of nitrosative stress is alkylation damage to DNA. To assess whether nitrosative stress is registered on the genome of Mycobacterium tuberculosis, mutants lacking an alkylation damage repair and reversal operon were constructed. Although hypersensitive to the genotoxic effects of N-methyl-N'-nitro-N-nitrosoguanidine in vitro, the mutants displayed no phenotype in vivo, suggesting...

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Identifiers

PMID: 12540583
DOI: 10.1128/IAI.71.2.997-1000.2003
PMCID: PMC145403

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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