Article
Adaptive evolution of the lactose utilization network in experimentally evolved populations of Escherichia coli.
PLoS genetics - 1 Jan 2012
Quan Selwyn, Ray J Christian J, Kwota Zakari, Duong Trang, Balázsi Gábor, Cooper Tim F, Monds Russell D
Abstract excerpt
Adaptation to novel environments is often associated with changes in gene regulation. Nevertheless, few studies have been able both to identify the genetic basis of changes in regulation and to demonstrate why these changes are beneficial. To this end, we have focused on understanding both how and why the lactose utilization network has evolved in replicate populations of Escherichia coli. We found that lac...
Topics
- Adaptation, Physiological
- Directed Molecular Evolution
- Environment
- Escherichia coli
- Escherichia coli Proteins
- Gene Expression Regulation, Bacterial
- Genetic Fitness
- Lac Operon
- Lac Repressors
- Lactose
- Metabolic Networks and Pathways
- Mutation
- Promoter Regions, Genetic