Article
Use of nested PCR for differential diagnosis of falciparum malaria reinfection and relapse in drug-resistant patients.
Bulletin of experimental biology and medicine - 1 Oct 2002
Van Ha Nguen, Dyk Dao Le, Rabinovich S A
Abstract excerpt
Microscopic examination does not allow differentiation of drug-resistant P. falciparum infection relapse from reinfection. However, this differential diagnosis is essential for adequate therapy. Three highly polymorphic P. falciparum genes (msp1, msp2, and glurp) and their alleles reflecting the structural state of these genes were used as genetic markers for differential diagnosis by PCR with internal primers....
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