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Molecular cloning and chimerisation of an inhibitory anti-cathepsin B antibody and its expression in Chinese hamster ovary cells.

Biological chemistry - 1 Nov 2002

Fan Xiaohui, Kopitar-Jerala Natasa, Premzl Ales, Bestagno Marco, Burrone Oscar, Kos Janko

Abstract excerpt

The lysosomal cysteine protease cathepsin B is one of several proteases that have been linked to tumour progression. Its increased expression and secretion in tumour cells may facilitate the degradation of extracellular matrix proteins, leading to tumour cell invasion and metastasis. Specific inhibitory monoclonal antibodies are a possible alternative to synthetic inhibitors as a therapeutic tool for cancer...

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PMID: 12530548
DOI: 10.1515/BC.2002.204

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