Article
Generation of monoclonal antibody targeting fibroblast growth factor receptor 3.
Hybridoma (2005) - 1 Aug 2009
Gorbenko Olena, Ovcharenko Galyna, Klymenko Tetyana, Zhyvoloup Olexandr, Gaman Nadia, Volkova Darija, Gout Ivan, Filonenko Valeriy
Abstract excerpt
Fibroblast growth factor receptor 3 (FGFR3) is a member of the FGFR family of receptor tyrosine kinases, whose function has been implicated in diverse biological processes, including cell proliferation, differentiation, survival, and tumorigenesis. Deregulation of FGFR3 signaling has been implicated with human pathologies, including cancer. Activating mutations in FGFR3 gene are frequently detected in bladder...
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