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Article

Genes in human obesity loci are causal obesity genes in C. elegans.

PLoS genetics - 1 Sept 2021

Ke Wenfan, Reed Jordan N, Yang Chenyu, Higgason Noel, Rayyan Leila, Wählby Carolina, Carpenter Anne E, Civelek Mete, O'Rourke Eyleen J

Abstract excerpt

Obesity and its associated metabolic syndrome are a leading cause of morbidity and mortality. Given the disease's heavy burden on patients and the healthcare system, there has been increased interest in identifying pharmacological targets for the treatment and prevention of obesity. Towards this end, genome-wide association studies (GWAS) have identified hundreds of human genetic variants associated with obesity....

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Identifiers

PMID: 34492009
DOI: 10.1371/journal.pgen.1009736
PMCID: PMC8462697

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