Article
Lytic JC virus infection in the kidneys of AIDS subjects.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Jan 2003
Boldorini Renzo, Omodeo-Zorini Elisabetta, Nebuloni Manuela, Benigni Elisabetta, Vago Luca, Ferri Angelita, Monga Guido
Abstract excerpt
Our objective was to investigate the role of the human polyomavirus JC virus as a possible cause of renal damage in AIDS subjects. Histology, immunohistochemistry, and molecular biology were used to evaluate the frequency of viral infection, genotypes, viral status, and the presence of rearrangements or point mutations in specific genomic regions of strains isolated from renal tissue. Formalin-fixed,...
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